Dominic Whittaker
QSP and Systems Modelling

A link to my Google Scholar page can be found here.

2024

• Mirams GR, Clerx M, Whittaker DG, Lei CL. "Optimal experimental designs for characterising ion channel gating by filling the phase-voltage space of model dynamics". Mathematics in Medical and Life Sciences, 2024, 1(1).
• Shuttleworth JG, Lei CL, Whittaker DG, Windley MJ, Hill AP, Preston SP, Mirams GR. "Empirical quantification of predictive uncertainty due to model discrepancy by training with an ensemble of experimental designs: An application to ion channel kinetics". Bull Math Biol, 2024, 86, 2.

2023

• Lei CL, Whittaker DG, Mirams GR. "The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk". Br J Pharmacol, 2023; 1-18.
• Whittaker DG*, Herrera-Reyes AD*, Hendrix M, Owen MR, Band LR, Mirams GR, Bolton KJ, Preston SP. "Uncertainty and error in SARS-CoV-2 epidemiological parameters inferred from population-level epidemic models". J Theor Biol, 2023, 111337.

2022

• Whittaker DG, Wang J, Shuttleworth JG, Venkateshappa R, Kemp JM, Claydon TW, Mirams GR. "Ion channel model reduction using manifold boundaries". J R Soc Interface, 2022, 20220193.
• Barral Y-SHM, Shuttleworth JG, Clerx M, Whittaker DG, Wang K, Polonchuk L, Gavaghan DJ, Mirams GR. "A parameter representing missing charge should be considered when calibrating action potential models". Front Physiol, 2022, 13, 879035.

2021

• Kemp JM, Whittaker DG, Venkateshappa R, Pang Z, Johal R, Sergeev V, Tibbits GF, Mirams GR, Claydon TW. "Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243". J Gen Physiol, 2021, 153 (10): e202112923.
• Whittaker DG, Capel RA, Hendrix M, Chan XHS, Herring N, White NJ, Mirams GR, Burton RAB. "Cardiac TdP risk stratification modelling of anti-infective compounds including chloroquine and hydroxychloroquine". R Soc Open Sci, 2021, 8: 210235.

2020

• Alghamdi AM, Testrow CP, Whittaker DG, Boyett MR, Hancox JC, Zhang H. "Mechanistic insights into the reduced pacemaking rate of the rabbit sinoatrial node during postnatal development: a simulation study". Front Physiol, 2020, 11, 547577.
• Lei CL, Fabbri A, Whittaker DG, Clerx M, Mirams GR, de Boer TP. "A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer". Wellcome Open Research, 2020, 5 (152), 152.
• Lei CL, Ghosh S, Whittaker DG, Aboelkassem Y, Beattie KA, Cantwell CD, Delhaas T, Houston C, Novaes GM, Panfilov AV, Pathmanathan P, Riabiz M, Walmsley J, Weber dos Santos R, Worden K, Mirams GR, Wilkinson RD. "Considering discrepancy when calibrating a mechanistic electrophysiology model". Phil Trans R Soc A, 2020, A.37820190349.
• Lei CL, Clerx M, Whittaker DG, Gavaghan DJ, de Boer TP, Mirams GR. "Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments". Phil Trans R Soc A, 2020, A 378 (2173), 20190348.
• Whittaker DG*, Clerx M*, Lei CL, Christini DJ, Mirams GR. "Calibration of ionic and cellular cardiac electrophysiology models". WIREs Syst Biol Med, 2020;e1482.
• Benson AP, Stevenson-Cocks HJ, Whittaker DG, White E, Colman MA. "Multi-scale approaches for the simulation of cardiac electrophysiology: II - tissue-level structure and function". Methods, 2020, S1046-2023(19)30224-5.
• Colman MA, Holmes M, Whittaker DG, Jayasinghe I, Benson AP. "Multi-scale approaches for the simulation of cardiac electrophysiology: I - sub-cellular and stochastic calcium dynamics from cell to organ". Methods, 2020 S1046-2023(19)30225-7.

2019

• Whittaker DG, Benson AP, Teh I, Schneider JE, Colman MA. "Investigation of the role of myocyte orientations in cardiac arrhythmia using image-based models". Biophys J, 2019, 117, 1–13.
• Hancox JC, Whittaker DG, Zhang H, Stuart AG. "Learning from studying very rare cardiac conditions: the example of short QT syndrome". J Congen Cardiol, 2019, 3:3.
• Perez Alday EA, Whittaker DG, Benson AP, Colman MA. "Effects of heart rate and ventricular wall thickness on non-invasive mapping: an in silico study". Front Physiol, 2019, 10, 308.
• Whittaker DG, Hancox JC, Zhang H. "In silico assessment of pharmacotherapy for human atrial patho-electrophysiology associated with hERG-linked short QT syndrome". Front Physiol, 2019, 9, 1888.

2018

• Whittaker DG, Colman MA, Ni H, Hancox JC, Zhang H. "Human atrial arrhythmogenesis and sinus bradycardia in KCNQ1-linked short QT syndrome: insights from computational modelling". Front Physiol, 2018, 9, 1402.
• Hancox JC, Whittaker DG, Du C, Stuart AG, Zhang H. "Emerging therapeutic targets in the short QT syndrome". Expert Opin Ther Targets, 2018, 22(5), pp.439-451.

2017

• Ni H, Whittaker DG, Wang W, Giles WR, Narayan S, Zhang H. "Synergistic anti-arrhythmic effects in human atria with combined use of sodium blockers and acacetin". Front Physiol, 2017, 8, 946.
• Whittaker DG, Ni H, Benson AP, Hancox JC, Zhang H. "Computational analysis of the mode of action of disopyramide and quinidine on hERG-linked short QT syndrome in human ventricles". Front Physiol, 2017, 8, 759.
• Adeniran I*, Whittaker DG*, El Harchi A, Hancox JC, Zhang H. "In silico investigation of a KCNQ1 mutation associated with short QT syndrome". Sci Rep, 2017, 7, pp. 8469.
• Whittaker DG, Ni H, El Harchi A, Hancox JC, Zhang H. "Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria". PLoS Comp Biol, 2017, 13, pp. e1005593.

2015

• Hancox JC, Adeniran I, Whittaker DG, Zhang H. "Altered in vivo systolic function in the short QT syndrome anticipated in silico". Heart Rhythm, 2015, 12, pp. e115.

• Lei CL, Whittaker DG, Windley MJ, Perry MD, Hill AP, Mirams GR. "A range of voltage-clamp protocol designs for rapid capture of hERG kinetics". bioRxiv, 2024.08.14.607756.
• Mirams GR, Clerx M, Whittaker DG, Lei CL. "Optimal experimental designs for characterising ion channel gating by filling the phase-voltage space of model dynamics". bioRxiv, 2024.05.02.592179. Now published.
• Lei CL, Whittaker DG, Mirams GR. "The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk". bioRxiv, 2023.03.14.532553. Now published.
• Shuttleworth JG, Lei CL, Whittaker DG, Windley MJ, Hill AP, Preston SP, Mirams GR. "Empirical quantification of predictive uncertainty due to model discrepancy by training with an ensemble of experimental designs: an application to ion channel kinetics". arXiv, 2302.02942, 2023. Now published.
• Whittaker DG*, Herrera Reyes AD*, Hendrix M, Owen MR, Band LR, Mirams GR, Bolton KJ, Preston SP. "Uncertainty and error in SARS-CoV-2 epidemiological parameters inferred from population-level epidemic models". medRxiv, 2022.07.01.22277134. Now published.
• Whittaker DG, Wang J, Shuttleworth JG, Venkateshappa R, Kemp JM, Claydon TW, Mirams GR. "Ion channel model reduction using manifold boundaries". bioRxiv, 2022.03.11.483794. Now published.
• Lei CL, Clerx M, Whittaker DG, Gavaghan DJ, de Boer TP, Mirams GR. "Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments". bioRxiv, 2019.12.20.884353. Now published.

* indicates authors contributed equally.

2024

• Whittaker DG, Shaliban A, Roy M, Packrisamy P, Rengaswamy M, Damian V, Gupta A. "Leveraging in vitro data from novel drug candidates to prioritize antibody combinations in autoimmune disease using a QSP model of IBD". PAGE 32 (2024) Abstr 10876. Rome, Italy.

2020

• Whittaker DG, Kemp J, Venkateshappa R, Mirams GR, Claydon TW. "Rapid characterisation of R56Q mutant hERG channel kinetics using sinusoidal voltage protocols". Biophysical Journal, 118 (3), 112a. San Diego, CA, USA, 2020.

2019

• Luo C, Whittaker DG, He Y, Liu T, Li Y, Wang K, Zhao N, Zhang H. "Effects of taurine-magnesium coordination compound on type 2 short QT syndrome: A simulation study". Computing in Cardiology (CinC), Singapore, 2019, pp. 1-4.
• Luo C, Whittaker DG, Liu T, Wang K, Li Y, He Y, Zhang H. "Pharmacotherapeutic effects of quinidine on short QT syndrome by using Purkinje-ventricle model: A simulation study". 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) , Berlin, Germany, 2019, pp. 2856-2859.

2018

• Whittaker DG, Benson AP, Teh I, Schneider JE, Colman MA. "Role of cardiac microstructure variability on ventricular arrhythmogenesis". Computing in Cardiology Conference (CinC), Maastricht, Netherlands, 2018, pp. 1-4.
• Whittaker DG, Hancox JC, Zhang H. "Modelling the effects of propafenone on human atrial patho-electrophysiology associated With hERG-linked short QT syndrome". Computing in Cardiology Conference (CinC), Maastricht, Netherlands, 2018, pp. 1-4.
• Alghamdi AM, Testrow CP, Whittaker DG, Zhang H. "The mechanism underlying heart rate and pacemaking activity decline in developing sinoatrial node of the rabbit heart". Computing in Cardiology Conference (CinC), Maastricht, Netherlands, 2018, pp. 1-4.
• Naser H, Whittaker DG, Shiels HA, Boyett MR, Zhang H. "A novel model of electrical action potentials of teleost fish ventricular myocytes". Computing in Cardiology Conference (CinC), Maastricht, Netherlands, 2018, pp. 1-4.
• Whittaker DG, Benson AP, Teh I, Schneider JE, Colman MA. "Computational assessment of the role of myocardial structural variability in ventricular arrhythmia dynamics". Europhysiology 2018 (London, UK) Proc Physiol Soc 41, PCB050.

2016

• Whittaker DG, Ni H, Benson AP, Hancox JC, Zhang H. "Modelling the effects of disopyramide on short QT syndrome variant 1 in the human ventricles". Computing in Cardiology Conference (CinC), Vancouver, BC, Canada, 2016, pp. 9-12.
• Ni H, Whittaker DG, Wang W, Zhang H. "Synergistic anti-arrhythmic effects of combined blockade of sodium and ultra-rapid delayed rectifier potassium channels in human atria". Computing in Cardiology Conference (CinC), Vancouver, BC, Canada, 2016, pp. 837-840.
• Wang W, Whittaker DG, Ni H, Wang K, Zhang H. "Two aspects of cardiac alternans – difference and correlation between them". Computing in Cardiology Conference (CinC), Vancouver, BC, Canada, 2016, pp. 1101-1104.
• Testrow CP, Whittaker DG, Holden AV, Zhang H. "Modelling the effects of nifedipine on ventricular and myometrial cells of pregnant rats". Computing in Cardiology Conference (CinC), Vancouver, BC, Canada, 2016, pp. 829-832.

2015

• Whittaker DG, Colman MA, Ni H, Hancox JC, Zhang H. "In silico investigation of short QT syndrome-linked potassium channel mutations on electro-mechanical function of human atrial cells". Computing in Cardiology Conference (CinC), Nice, France, 2015, pp. 853-856.
• Whittaker DG, Colman MA, Hancox JC, Zhang H. "In silico study of the effects of hERG-linked short QT syndrome on the electrical and mechanical activities of human atrial cells". Physiology 2015 (Cardiff, UK) Proc Physiol Soc 34, PC163.

• Hancox JC, McPate MJ, El Harchi A, Butler AS, Zhang Y, Whittaker DG, Dempsey CE, Witchel HJ, Adeniran I, Stuart AG, Zhang H. "The Short QT Syndrome". In: Tripathi ON, Quinn TA, Ravens U. (eds) Heart Rate and Rhythm. Springer, Cham. 2023.

• Whittaker DG. "Pathophysiology and pharmacology of short QT syndrome gene mutations in the human atria: Insights from multi-scale computational modelling". The University of Manchester (United Kingdom) ProQuest Dissertations Publishing, 2018. 27680065.

• Colman MA, Benson AP. "A simple approach for image‑based modelling of the heart that enables robust simulation of highly heterogeneous electrical excitation". Sci Rep, 2023, 13, 15119.
• Clerx M, Mirams GR, Rogers AJ, Narayan SM, Giles WR. "Immediate and delayed response of simulated human atrial myocytes to clinically-relevant hypokalemia". Front Physiol, 2021, 12:651162.

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